Question is under high pressure of research doctors and biologists: is the how to preserve motor nerve cells from dying? A research team from Bochum has now reviewed the vitamin P under the microscope – with positive results.
Damage to the motor neurons can lead to various diseases, such as amyotrophic lateral sclerosis for, increasing muscle weakness, muscle atrophy and muscle spasms occur in the course. You can show the mouse model that the. Molecule 7,8-dihydroxyflavone, also called vitamin P, can protect the motor neurons from dying.
Until now it was assumed that vitamin acts similar to the nerve nutrient BDNF (Brain Derived Neurotrophic Factor). Attempts to prevent by means of BDNF damage to the motor neurons, but had only moderate success and in some cases even negative consequences show how one of the study authors explained. Therefore we are looking for alternative opportunities and to new approaches for the treatment of neurodegenerative diseases such as finding of amyotrophic lateral sclerosis.
Vitamin P and BDNF: Different mode of action.
The theory that vitamin P and BDNF act in the same way, could now be disprove. Although both substances have the result that isolated motor neurons mouse survive in culture and make new extensions. However, while BD NF switch two signal paths, namely the so-called MAP kinase and PI3K / AKT signaling pathways, the Vitamin P operated however only the latter.
In addition, it is extremely important to follow the proper dosage of vitamin P, because it exerts its beneficial effects on motor neurons only in a very small concentration range. An overdose on the other hand reduces the survival effect. The researchers now hope that vitamin P has less negative side effects than BDNF. Since it may happen, in contrast to BDNF even the blood-brain barrier and therefore do not need to be introduced via pump into the cerebrospinal fluid, and the application would be easier.